azd-9291
分子量：499.61[1] 
分子式：c28h33n7o2
cas号：1421373-65-0
包装：铝箔袋
货期：现货
产品资料介绍
 azd-9291 is a potent and selective mutated forms egfr inhibitor(exon 19 deletion egfr ic50=12.92 nm, l858r/t790m egfr ic50= 11.44 nm, wild type egfr ic50= 493.8 nm).
ic50 value: 12.92 nm(exon 19 deletion egfr); 11.44 nm(l858r/t790m egfr) [1]
target: l858r/t790m egfr; exon 19 deletion egfr
azd-9291 is a third-generation egfr inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing egfr inhibitors. azd9291 is highly active in preclinical models and is well tolerated in animal models. it inhibits both activating and resistant egfr mutations while sparing the normal form of egfr that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines.
技术资料
      azd9291是第三代口服、不可逆的选择性egfr突变抑制剂，可用于激活的和抗性突变的egfr，50%的抗egfr获得性耐，azd9291可使这一挑战性的突变无效。
 azd9291对于野生型egfr的效果很小，因此比现有的egfr抑制剂副作用更小
azd9291强效抵抗t790m所有抗肿瘤新药仅供科研使用
azd9291是一个口服的、不可逆的、第三代选择性egfr抑制剂，可作用于激活的egfr和抗性突变的egfr（t790m）。 
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